Citation
Case-based Reasoning for the Analysis of Methylation Data in Oncology

Material Information

Title:
Case-based Reasoning for the Analysis of Methylation Data in Oncology
Creator:
Chris Bartlett
Guanghui Liu
Isabelle Bichindaritz
Publication Date:

Subjects

Subjects / Keywords:
Bioinformatics
Oncology

Notes

Abstract:
Christopher Bartlett, Guanghui Liu, Isabelle Bichindaritz Abstract: One biomarker, DNA methylation, has recently become more prevalent in genetic research studies in oncology for its ability to differentiate cancer subtypes. We seek to apply these findings in a study of the diagnostic accuracy of DNA methylation signatures for classifying metastatic cancer tissue. High classification performance measures were obtained from differentially methylated positions, regions and selected gene signatures. Perfect accuracy was achieved with the top 5 feature-selected genes. This work contributes to the path toward the identification of biological signatures for oncology samples using case-based reasoning.
Acquisition:
Collected for SUNY Oswego Institutional Repository by the online self-submittal tool. Submitted by Isabelle Bichindaritz.

Record Information

Source Institution:
SUNY Oswego Institutional Repository
Holding Location:
SUNY Oswego Institution
Rights Management:
All applicable rights reserved by the source institution and holding location.

Downloads

This item is only available as the following downloads:


Full Text

PAGE 1

&DVHEDVHG5HDVRQLQJIRUWKH$QDO\VLVRI 0HWK\ODWLRQ'DWDLQ2QFRORJ\ &KULVWRSKHU%DUWOHWWDQG,VDEHOOH%LFKLQGDULW] &$6(%$6('5($621,1* &DVH%DVHG5HDVRQLQJ&%5LVXVLQJ SUHYLRXVH[SHULHQFHVWRXQGHUVWDQGDQGVROYH QHZSUREOHPV ³$FDVHEDVHGUHDVRQHUVROYHVQHZSUREOHPV E\DGDSWLQJVROXWLRQVWKDWZHUHXVHGWRVROYH ROGSUREOHPV´ 5LHVEHFN6FKDQN 5 HWULHYH :KHQDQHZSUREOHPLVSUHVHQWHGVLPLODU FDVHVDUHUHWULHYHGIURPPHPRU\ 5 HXVH 7KHVROXWLRQRIWKHUHWULHYHGFDVHVDUH UHXVHG 5 HYLVH 7KHVROXWLRQLVUHYLVHGWRILWWKHQHZ SUREOHP 5 HWDLQ 7KHUHYLVHGVROXWLRQLVUHWDLQHGIRUIXWXUH XVH '1$0(7+