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Case-based Reasoning for the Analysis of Methylation Data in Oncology
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Open-NJ Link:
https://digitallibrary.oswego.edu/SUOS000852/00001
Material Information
Title:
Case-based Reasoning for the Analysis of Methylation Data in Oncology
Creator:
Chris Bartlett
Guanghui Liu
Isabelle Bichindaritz
Publication Date:
03/31/2020
Subjects
Subjects / Keywords:
Bioinformatics
Oncology
Notes
Abstract:
Christopher Bartlett, Guanghui Liu, Isabelle Bichindaritz Abstract: One biomarker, DNA methylation, has recently become more prevalent in genetic research studies in oncology for its ability to differentiate cancer subtypes. We seek to apply these findings in a study of the diagnostic accuracy of DNA methylation signatures for classifying metastatic cancer tissue. High classification performance measures were obtained from differentially methylated positions, regions and selected gene signatures. Perfect accuracy was achieved with the top 5 feature-selected genes. This work contributes to the path toward the identification of biological signatures for oncology samples using case-based reasoning.
Acquisition:
Collected for SUNY Oswego Institutional Repository by the online self-submittal tool. Submitted by Isabelle Bichindaritz.
Record Information
Source Institution:
SUNY Oswego Institutional Repository
Holding Location:
SUNY Oswego Institution
Rights Management:
All applicable rights reserved by the source institution and holding location.
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